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Article

Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990

Goodman L E, Judd S R, Farnsworth C C, Powers S, Gelb M H, Glomset J A, Tamanoi F

Abstract excerpt

Ras proteins are post-translationally modified by farnesylation. In the present investigation, we identified an activity in crude soluble extracts of yeast cells that catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to yeast RAS2 protein. RAS2 proteins having a C-terminal Cys-Ali-Ali-Xaa sequence (where Ali is an aliphatic amino acid and Xaa is the unspecified C-terminal amino acid) served...

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Identifiers

PMID: 2124698
DOI: 10.1073/pnas.87.24.9665
PMCID: PMC55233

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