Article
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990
Goodman L E, Judd S R, Farnsworth C C, Powers S, Gelb M H, Glomset J A, Tamanoi F
Abstract excerpt
Ras proteins are post-translationally modified by farnesylation. In the present investigation, we identified an activity in crude soluble extracts of yeast cells that catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to yeast RAS2 protein. RAS2 proteins having a C-terminal C...
Topics
- Alkyl and Aryl Transferases
- Amino Acid Sequence
- Fungal Proteins
- GTP-Binding Proteins
- Genes, Fungal
- Kinetics
- Molecular Sequence Data
- Mutation
- Protein Processing, Post-Translational
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transferases
- ras Proteins