Article
Post-translational processing of purified human K-ras in Xenopus oocytes.
Cancer communications - 1 Jan 1991
Kaplan J B, Sass P M
Abstract excerpt
Membrane localization of ras p21 involves a complex series of post-translational processing events, including S-farnesylation of Cys-186, removal of three carboxyl-terminal amino acid residues, and methylation of the carboxyl-terminal farnesylcysteine residue. Palmitoylation of cysteine residues within the hypervariable region (amino acids 165-185) is also required for membrane localization of mammalian H-, N-,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.