Article
Development of inhibitors of protein farnesylation as potential chemotherapeutic agents.
Journal of cellular biochemistry. Supplement - 1 Jan 1995
Kohl N E, Conner M W, Gibbs J B, Graham S L, Hartman G D, Oliff A
Abstract excerpt
Protein prenylation, adding either the 15-carbon isoprenoid farnesyl or the 20-carbon isoprenoid geranylgeranyl to cysteine residue(s) at or near the C-termini of proteins, is a recently identified post-translational modification that localizes some proteins to a membrane compartment. One of the most intensely studied prenylated proteins is Ras, a low molecular weight GTP-binding protein that plays an important...
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