Development of inhibitors of protein farnesylation as potential chemotherapeutic agents.

doi:10.1002/jcb.240590819

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Article

Development of inhibitors of protein farnesylation as potential chemotherapeutic agents.

Journal of cellular biochemistry. Supplement - 1 Jan 1995

Kohl N E, Conner M W, Gibbs J B, Graham S L, Hartman G D, Oliff A

Abstract excerpt

Protein prenylation, adding either the 15-carbon isoprenoid farnesyl or the 20-carbon isoprenoid geranylgeranyl to cysteine residue(s) at or near the C-termini of proteins, is a recently identified post-translational modification that localizes some proteins to a membrane compartment. One of the...

Topics

Amino Acid Sequence
Animals
Antineoplastic Agents
Enzyme Inhibitors
Humans
Molecular Sequence Data
Mutation
Oligopeptides
Protein Prenylation
Structure-Activity Relationship
ras Proteins

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