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Article

ras protein p21 processing enzyme farnesyltransferase in chemical carcinogen-induced murine skin tumors.

Molecular carcinogenesis - 1 Jan 1993

Agarwal R, Khan S G, Athar M, Zaidi S I, Bickers D R, Mukhtar H

Abstract excerpt

Farnesylation of ras protein p21 is crucial for the protein's membrane localization, which is essential for its cell-transforming activity, which in turn is thought to be critical for the ultimate induction of cancer. The cytosolic enzyme farnesyltransferase plays a major role in posttranslational modification of p21, but the level of farnesyltransferase activity in mammalian tumors and its relationship to the...

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PMID: 8280377
DOI: 10.1002/mc.2940080412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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