Article
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Jackson J H, Cochrane C G, Bourne J R, Solski P A, Buss J E, Der C J
Abstract excerpt
Oncogenic forms of ras proteins are synthesized in the cytosol and must become membrane associated to cause malignant transformation. Palmitic acid and an isoprenoid (farnesol) intermediate in cholesterol biosynthesis are attached to separate cysteine residues near the C termini of H-ras, N-ras, and Kirsten-ras (K-ras) exon 4A-encoded proteins. These lipid modifications have been suggested to promote or stabilize...
Topics
- Animals
- Anticholesteremic Agents
- Cell Line
- Cell Transformation, Neoplastic
- Cells, Cultured
- Exons
- Farnesol
- Genetic Vectors
- Humans
- Lovastatin
- Mevalonic Acid