Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Duronio R J, Jackson-Machelski E, Heuckeroth R O, Olins P O, Devine C S, Yonemoto W, Slice L W, Taylor S S, Gordon J I

Abstract excerpt

Protein N-myristoylation refers to the covalent attachment of a myristoyl group (C14:0), via amide linkage, to the NH2-terminal glycine residue of certain cellular and viral proteins. Myristoyl-CoA:protein N-myristoyltransferase (NMT) catalyzes this cotranslational modification. We have developed a system for studying the substrate requirements and biological effects of protein N-myristoylation as well as NMT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Kinetics

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 2406721
DOI: 10.1073/pnas.87.4.1506
PMCID: PMC53504

Genes

NMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.PMID 2406721Read ↗

Use of Escherichia coli strains containing fad mutations plus a triple plasmid expression system to study the import of myristate, its activation by Saccharomyces cerevisiae acyl-CoA synthetase, and its utilization by S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase.Semantic proximity Read ↗

A Single Mutation in the "DSL" Motif of the Acyl Carrier Protein Can Prevent Its In Vivo Phosphopantetheinylation by E. coli Holo-Acyl Carrier Protein Synthase (AcpS).Semantic proximity Read ↗

Sequence-independent acylation of the vaccinia virus A-type inclusion protein.Semantic proximity Read ↗

Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy.Semantic proximity Read ↗

Suppressors of nmtl-181, a conditional lethal allele of the Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase gene, reveal proteins involved in regulating protein N-myristoylation.Semantic proximity Read ↗

Genetic studies reveal that myristoylCoA:protein N-myristoyltransferase is an essential enzyme in Candida albicans.Semantic proximity Read ↗

Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entrySemantic proximity Read ↗

Functional significance of myristoyl moiety in N-myristoyl proteins.Semantic proximity Read ↗

Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.Semantic proximity Read ↗

A role for Saccharomyces cerevisiae fatty acid activation protein 4 in regulating protein N-myristoylation during entry into stationary phase.Semantic proximity Read ↗

Unexpected protein families including cell defense components feature in the N-myristoylome of a higher eukaryote.Semantic proximity Read ↗

Noncanonical amino acids in the interrogation of cellular protein synthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.