Article
Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.
Biochemistry - 18 May 1993
Omer C A, Kral A M, Diehl R E, Prendergast G C, Powers S, Allen C M, Gibbs J B, Kohl N E
Abstract excerpt
We have isolated cDNAs encoding the alpha and beta subunits of human farnesyl-protein transferase (FPTase). The proteins encoded by these two cDNAs are 93-95% identical to the corresponding subunits of bovine and rat FPTase and show regions of homology with proteins encoded by Saccharomyces cerev...
Topics
- Alkyl and Aryl Transferases
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Cloning, Molecular
- DNA
- Escherichia coli
- Farnesyltranstransferase
- Gene Expression
- Humans
- Kinetics
- Molecular Sequence Data
- Mutation
- Polyisoprenyl Phosphates