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Article

Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.

The Journal of biological chemistry - 26 Mar 1999

Kim E, Ambroziak P, Otto J C, Taylor B, Ashby M, Shannon K, Casey P J, Young S G

Abstract excerpt

Little is known about the enzyme(s) required for the endoproteolytic processing of mammalian Ras proteins. We identified a mouse gene (designated Rce1) that shares sequence homology with a yeast gene (RCE1) implicated in the proteolytic processing of Ras2p. To define the role of Rce1 in mammalian Ras processing, we generated and analyzed Rce1-deficient mice. Rce1 deficiency was lethal late in embryonic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10085069
DOI: 10.1074/jbc.274.13.8383

Genes

RCE1
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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