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Article

Substrate specificity determinants in the farnesyltransferase beta-subunit.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 1997

Trueblood C E, Boyartchuk V L, Rine J

Abstract excerpt

Protein prenyltransferases catalyze the covalent attachment of isoprenoid lipids (farnesyl or geranylgeranyl) to a cysteine near the C terminus of their substrates. This study explored the specificity determinants for interactions between the farnesyltransferase of Saccharomyces cerevisiae and its protein substrates. A series of substitutions at amino acid 149 of the farnesyltransferase beta-subunit were tested...

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Identifiers

PMID: 9380709
DOI: 10.1073/pnas.94.20.10774
PMCID: PMC23482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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