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Report on stage III Pig-a mutation assays using benzo[a]pyrene.

Environmental and molecular mutagenesis - 1 Dec 2011

Bhalli Javed A, Shaddock Joseph G, Pearce Mason G, Dobrovolsky Vasily N, Cao Xuefei, Heflich Robert H, Vohr Hans-Werner

Abstract excerpt

Genotoxicity assays were conducted on rats treated with benzo[a]pyrene (BaP) as part of Stage III of a validation study on the Pig-a gene mutation assay. Assays were performed at the U.S. FDA-NCTR and Bayer-Germany. Starting on Day 1, groups of five 6- to 7-week-old male Fischer 344 (F344, used at FDA-NCTR) and Han Wistar rats (Bayer) were given 28 daily doses of 0, 37.5, 75, or 150 mg/kg BaP; blood was sampled...

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PMID: 22052432
DOI: 10.1002/em.20675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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