Article
Characterisation of an in vivo Pig-a gene mutation assay for use in regulatory toxicology studies.
Mutagenesis - 1 May 2015
Godin-Ethier Jessica, Leroux Francis, Wang Nan, Thébaud Sybil, Merah Farida, Nelson Andrew
Abstract excerpt
Integration of in vivo genotoxicity testing into standard toxicology studies presents multiple advantages as it reduces animal use and costs, accelerates data generation and provides concurrent data that are useful for interpreting results. The in vivo Pig-a assay is a mammalian gene mutation assay that utilises peripheral blood and thus has a high integration potential. Although inter-laboratory reproducibility...
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