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Article

Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethane.

Mutagenesis - 1 May 2015

Stankowski Leon F, Aardema Marilyn J, Lawlor Timothy E, Pant Kamala, Roy Shambhu, Xu Yong, Elbekai Reem

Abstract excerpt

As part of the international Pig-a validation trials, we examined the induction of Pig-a mutant reticulocytes and red blood cells (RET(CD59-) and RBC(CD59-), respectively) in peripheral blood of male Sprague Dawley(®) rats treated with urethane (25, 100 and 250mg/kg/day) or saline by oral gavage for 29 days. Additional endpoints integrated into this study were: micronucleated reticulocytes (MN-RET) in peripheral...

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Identifiers

PMID: 25934985
DOI: 10.1093/mutage/gev013
PMCID: PMC4506322

Genes

CD59
RET
PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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