Article
In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs.
Environmental and molecular mutagenesis - 1 Jul 2012
Torous Dorothea K, Phonethepswath Souk, Avlasevich Svetlana L, Mereness Jared, Bryce Steven M, Bemis Jeffrey C, Weller Pamela, Bell Sara, Gleason Carol, Custer Laura L, MacGregor James T, Dertinger Stephen D
Abstract excerpt
Combining multiple genetic toxicology endpoints into a single in vivo study, and/or integrating one or more genotoxicity assays into general toxicology studies, is attractive because it reduces animal use and enables comprehensive comparative analysis using toxicity, metabolism, and pharmacokinet...
Topics
- Animals
- Benzo(a)pyrene
- Carcinogens, Environmental
- Dose-Response Relationship, Drug
- Erythrocytes
- Flow Cytometry
- Genetic Loci
- Male
- Membrane Proteins
- Micronucleus Tests
- Mutation
- Pyrenes
- Rats