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Article

Pig-a gene mutation assay study design: critical assessment of 3- versus 28-day repeat-dose treatment schedules.

Mutagenesis - 12 Sept 2020

Elhajouji Azeddine, Hove Tamsanqa Tafara, O'Connell Oliver, Martus Hansjoerg, Dertinger Stephen D

Abstract excerpt

The in vivo Pig-a assay is being used in safety studies to evaluate the potential of chemicals to induce somatic cell gene mutations. Ongoing work is aimed at developing an Organisation for Economic Cooperation and Development (OECD) test guideline to support routine use for regulatory purposes (OECD project number 4.93). Among the details that will need to be articulated in an eventual guideline are recommended...

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PMID: 32608486
DOI: 10.1093/mutage/geaa014
PMCID: PMC7486680

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