Article
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.
European heart journal - 1 Jan 2012
Grallert Harald, Dupuis Josée, Bis Joshua C, Dehghan Abbas, Barbalic Maja, Baumert Jens, Lu Chen, Smith Nicholas L, Uitterlinden André G, Roberts Robert, Khuseyinova Natalie, Schnabel Renate B, Rice Kenneth M, Rivadeneira Fernando, Hoogeveen Ron C, Fontes João Daniel, Meisinger Christa, Keaney John F, Lemaitre Rozenn, Aulchenko Yurii S, Vasan Ramachandran S, Ellis Stephen, Hazen Stanley L, van Duijn Cornelia M, Nelson Jeanenne J, März Winfried, Schunkert Heribert, McPherson Ruth M, Stirnadel-Farrant Heide A, Psaty Bruce M, Gieger Christian, Siscovick David, Hofman Albert, Illig Thomas, Cushman Mary, Yamamoto Jennifer F, Rotter Jerome I, Larson Martin G, Stewart Alexandre F R, Boerwinkle Eric, Witteman Jacqueline C M, Tracy Russell P, Koenig Wolfgang, Benjamin Emelia J, Ballantyne Christie M
Abstract excerpt
AIMS: Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates proinflammatory and proatherogenic compounds in the arterial vascular wall and is a potential therapeutic target in coronary heart disease (CHD). We searched for genetic loci related to Lp-PLA2 mass or activity by a genome-wide association study as part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. METHODS...
Read the complete abstract on PubMed