PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry.

doi:10.1161/CIRCULATIONAHA.109.923383

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Article

PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry.

Circulation - 1 Jun 2010

Casas Juan P, Ninio Ewa, Panayiotou Andrie, Palmen Jutta, Cooper Jackie A, Ricketts Sally L, Sofat Reecha, Nicolaides Andrew N, Corsetti James P, Fowkes F Gerry R, Tzoulaki Ioanna, Kumari Meena, Brunner Eric J, Kivimaki Mika, Marmot Michael G, Hoffmann Michael M, Winkler Karl, März Winfred, Ye Shu, Stirnadel Heide A, Boekholdt S Matthijs, Khaw Kay-Tee, Humphries Steve E, Sandhu Manjinder S, Hingorani Aroon D, Talmud Philippa J

Abstract excerpt

BACKGROUND: Higher lipoprotein-associated phospholipase A(2)(Lp-PLA2) activity is associated with increased risk of coronary heart disease (CHD), making Lp-PLA2 a potential therapeutic target. PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal. METHODS AND RESULTS: A meta-analysis including a total of 12 studies (5 prospective, 4 case-control, 1 case-only, and 2...

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PMID: 20479152
DOI: 10.1161/CIRCULATIONAHA.109.923383
PMCID: PMC3377948

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