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Article

PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk.

Circulation. Cardiovascular genetics - 1 Apr 2015

Guardiola Montse, Exeter Holly J, Perret Claire, Folkersen Lasse, Van't Hooft Ferdinand, Eriksson Per, Franco-Cereceda Anders, Paulsson-Berne Gabrielle, Palmen Jutta, Li KaWah, Cooper Jackie A, Khaw Kay-Tee, Mallat Ziad, Ninio Ewa, Karabina Sonia-Athina, Humphries Steve E, Boekholdt S Matthijs, Holmes Michael V, Talmud Philippa J

Abstract excerpt

BACKGROUND: Observational studies report that secretory phospholipase A2 (sPLA2) activity is a marker for coronary heart disease (CHD) risk, and activity measures are thought to represent the composite activity of sPLA2-IIA, -V, and -X. The aim of this study was to use genetic variants of PLA2G10, encoding sPLA2-X, to investigate the contribution of sPLA2-X to the measure of sPLA2 activity and coronary heart...

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PMID: 25583995
DOI: 10.1161/CIRCGENETICS.114.000633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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