Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.

doi:10.1136/heartjnl-2020-316722

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Article

Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.

Heart (British Cardiac Society) - 1 Sept 2020

Perrot Nicolas, Thériault Sébastien, Rigade Sidwell, Chen Hao Yu, Dina Christian, Martinsson Andreas, Boekholdt S Matthijs, Capoulade Romain, Le Tourneau Thierry, Messika-Zeitoun David, Engert James C, Wareham Nicholas J, Clavel Marie-Annick, Pibarot Philippe, Smith J Gustav, Schott Jean Jacques, Mathieu Patrick, Bossé Yohan, Thanassoulis George, Arsenault Benoit J

Abstract excerpt

BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been shown to predict calcific aortic valve stenosis (CAVS) outcomes. Our objective was to test the association between plasma Lp-PLA2 activity and genetically elevated Lp-PLA2 mass/activity with CAVS in humans. METHODS AND RESULTS: Lp-PLA2 activity was measured in 890 patients undergoing cardiac surgery, including 476 patients undergoing...

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PMID: 32636298
DOI: 10.1136/heartjnl-2020-316722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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