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Article

Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.

Circulation. Cardiovascular genetics - 1 Dec 2012

Chu Audrey Y, Guilianini Franco, Grallert Harald, Dupuis Josée, Ballantyne Christie M, Barratt Bryan J, Nyberg Fredrik, Chasman Daniel I, Ridker Paul M

Abstract excerpt

BACKGROUND: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a proinflammatory enzyme bound to low-density lipoprotein cholesterol and other circulating lipoproteins. Two measures of Lp-PLA(2), mass and activity, are associated with increased cardiovascular risk. Data are sparse regarding genetic determinants of Lp-PLA(2) mass and activity, and no prior data are available addressing genetic determinants...

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Source

Identifiers

PMID: 23118302
DOI: 10.1161/CIRCGENETICS.112.963314

Genes

ABCG2
LPA
APOC1
APOE
CETP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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