Article
Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study.
Atherosclerosis - 1 Jun 2009
Schnabel Renate, Dupuis Josée, Larson Martin G, Lunetta Kathryn L, Robins Sander J, Zhu Yanyan, Rong Jian, Yin Xiaoyan, Stirnadel Heide A, Nelson Jeanne J, Wilson Peter W F, Keaney John F, Vasan Ramachandran S, Benjamin Emelia J
Abstract excerpt
OBJECTIVE: To conduct an investigation of clinical and genetic correlates of lipoprotein-associated phospholipase (Lp-PLA(2)) activity and mass in a large community-based cohort. Higher circulating Lp-PLA(2) predicts cardiovascular disease risk, but sources of inter-individual variability are incompletely understood. METHODS: We conducted stepwise regression of clinical correlates of Lp-PLA(2) in four Framingham...
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