Article
A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults.
International journal of epidemiology - 1 Oct 2016
Millwood Iona Y, Bennett Derrick A, Walters Robin G, Clarke Robert, Waterworth Dawn, Johnson Toby, Chen Yiping, Yang Ling, Guo Yu, Bian Zheng, Hacker Alex, Yeo Astrid, Parish Sarah, Hill Michael R, Chissoe Stephanie, Peto Richard, Cardon Lon, Collins Rory, Li Liming, Chen Zhengming
Abstract excerpt
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been implicated in development of atherosclerosis; however, recent randomized trials of Lp-PLA2 inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be used to assess the effects of genetically determined lower Lp-PLA2 METHODS: PLA2G7 V279F (rs76863441) was genotyped in 91...
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