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Article

Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.

PLoS genetics - 29 Apr 2010

Suchindran Sunil, Rivedal David, Guyton John R, Milledge Tom, Gao Xiaoyi, Benjamin Ashlee, Rowell Jennifer, Ginsburg Geoffrey S, McCarthy Jeanette J

Abstract excerpt

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of this enzyme are heritable traits, but major genetic determinants have not been explored in a systematic, genome-wide fashion. We carried out a genome-wide association study of Lp-PLA(2) activity and mass in 6,668 Caucasian subjects from the population-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20442857
DOI: 10.1371/journal.pgen.1000928
PMCID: PMC2861686

Genes

APOA1
APOA5
APOC1
APOE
BUD13
CELSR2
PSRC1
SCARB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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