Article
Expression level of miR-34a rather than P53 gene status correlates with mutability in related human lymphoblast cell lines.
Molecular carcinogenesis - 1 Aug 2012
Chen Xinrong, Yan Jian, Chen Tao
Abstract excerpt
The P53 gene is a tumor suppressor gene and can prevent mutation and tumor induction though apoptosis and DNA repair when it is activated by genotoxic stress. miR-34a expression is regulated by the P53 gene and might be required for cell response to DNA damage. TK6 cells are human lymphoblast cells with normal P53 function while WTK1 and NH32 cells derived from the same progenitor as TK6 cells are P53-deficient....
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