Article
microRNA-34a promotes DNA damage and mitotic catastrophe.
Cell cycle (Georgetown, Tex.) - 15 Nov 2013
Kofman Alexander V, Kim Jungeun, Park So Yeon, Dupart Evan, Letson Christopher, Bao Yongde, Ding Kai, Chen Quan, Schiff David, Larner James, Abounader Roger
Abstract excerpt
Efficient and error-free DNA repair is critical for safeguarding genome integrity, yet it is also linked to radio- and chemoresistance of malignant tumors. miR-34a, a potent tumor suppressor, influences a large set of p53-regulated genes and contributes to p53-mediated apoptosis. However, the eff...
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