microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.

doi:10.1182/blood-2009-07-234823

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Article

microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.

Blood - 27 May 2010

Asslaber Daniela, Piñón Josefina D, Seyfried Irina, Desch Petra, Stöcher Markus, Tinhofer Inge, Egle Alexander, Merkel Olaf, Greil Richard

Abstract excerpt

In chronic lymphocytic leukemia (B-CLL), aberrations along the p53 axis lead to decreased overall survival and therapy resistance. Recent studies identified microRNA-34a (miR-34a) as a major downstream target of p53. We monitored the expression of miR-34a during disease development in a murine B-CLL model. miR-34a was up-regulated more than 20-fold during the leukemic but not during the preleukemic phase. In the...

Topics

Aged
Aged, 80 and over
Animals
Apoptosis
Case-Control Studies
Disease-Free Survival
Female
Gene Expression Regulation, Leukemic
Genes, p53
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Introns

Leukemia, Experimental

Leukemia, Lymphocytic, Chronic, B-Cell

Male

Mice

Mice, Inbred C57BL

Mice, Transgenic

Source

Open in PubMed

Identifiers

PMID: 20089965
DOI: 10.1182/blood-2009-07-234823

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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