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Article

microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.

Blood - 27 May 2010

Asslaber Daniela, Piñón Josefina D, Seyfried Irina, Desch Petra, Stöcher Markus, Tinhofer Inge, Egle Alexander, Merkel Olaf, Greil Richard

Abstract excerpt

In chronic lymphocytic leukemia (B-CLL), aberrations along the p53 axis lead to decreased overall survival and therapy resistance. Recent studies identified microRNA-34a (miR-34a) as a major downstream target of p53. We monitored the expression of miR-34a during disease development in a murine B-CLL model. miR-34a was up-regulated more than 20-fold during the leukemic but not during the preleukemic phase. In the...

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Share to Disease-Free Survival
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Leukemia, Experimental

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to MicroRNAs

Share to Proto-Oncogene Proteins c-mdm2

Share to RNA, Neoplasm

Source

Identifiers

PMID: 20089965
DOI: 10.1182/blood-2009-07-234823

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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