Article
The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line.
Mutation research - 3 Jan 1997
Xia F, Liber H L
Abstract excerpt
Abnormalities in the p53 gene play an important role in genomic instability and tumorigenesis. Our previous work showed that p53 status is correlated with differential mutability in two closely related human lymphoblastoid cell lines, TK6 and WTK1. WTK1 cells, which contain a mutation in p53 (p53...
Topics
- Alleles
- Apoptosis
- Blotting, Western
- Cells, Cultured
- Enzyme-Linked Immunosorbent Assay
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Lymphocytes
- Mutagenesis
- Plasmids
- Recombination, Genetic
- Thymidine Kinase
- Transfection