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Article

The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line.

Mutation research - 3 Jan 1997

Xia F, Liber H L

Abstract excerpt

Abnormalities in the p53 gene play an important role in genomic instability and tumorigenesis. Our previous work showed that p53 status is correlated with differential mutability in two closely related human lymphoblastoid cell lines, TK6 and WTK1. WTK1 cells, which contain a mutation in p53 (p53Ile237) show a remarkably increased mutability, larger genetic alterations at the thymidine kinase locus (tk), an...

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Identifiers

PMID: 9015157
DOI: 10.1016/s0027-5107(96)00193-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line.PMID 9015157Read ↗

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