Spectra of spontaneous and X-ray-induced mutations at the hprt locus in related human lymphoblast cell lines that express wild-type or mutant p53.

Article

Spectra of spontaneous and X-ray-induced mutations at the hprt locus in related human lymphoblast cell lines that express wild-type or mutant p53.

Radiation research - 1 Sept 1995

Phillips E N, Xia F, Kelsey K T, Liber H L

Abstract excerpt

Previous work showed that WTK1 human lymphoblastoid cells are radioresistant but more sensitive to X-ray-induced mutation than the closely related line TK6. In addition, WTK1 cells contain a mutant p53 while in TK6 cells p53 is wild-type. In this work, we examined the spectra of 68 X-ray-induced...

Topics

Base Sequence
Cell Line
Genetic Linkage
Humans
Hypoxanthine Phosphoribosyltransferase
Lymphocytes
Molecular Sequence Data
Mutation
Tumor Suppressor Protein p53
X Chromosome
X-Rays

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