Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced levels of miR-34a in neuroblastoma are not caused by mutations in the TP53 binding site.

Genes, chromosomes & cancer - 1 Jul 2009

Feinberg-Gorenshtein Galina, Avigad Smadar, Jeison Marta, Halevy-Berco Gili, Mardoukh Jacques, Luria Drorit, Ash Shifra, Steinberg Ran, Weizman Avraham, Yaniv Isaac

Abstract excerpt

Neuroblastoma (NB) is the most common extracranial solid tumor in children below the age of 5 years. miR-34a, located in chromosome band 1p36, has been recently implicated as a tumor suppressor gene in NB. In addition, it has been shown that miR-34a is activated by TP53 by binding to a TP53 binding site upstream to the mature miR-34a. We studied NB tumors from 57 patients for miR-34a expression levels, 1p status,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Data Interpretation, Statistical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Infant

Share to Infant, Newborn

Share to MicroRNAs

Share to Neuroblastoma

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 19373781
DOI: 10.1002/gcc.20662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced levels of miR-34a in neuroblastoma are not caused by mutations in the TP53 binding site.PMID 19373781Read ↗

A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor GeneSemantic proximity Read ↗

microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review).Semantic proximity Read ↗

Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis.Semantic proximity Read ↗

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cellsSemantic proximity Read ↗

p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequentSemantic proximity Read ↗

Early Targets of miR-34a in NeuroblastomaSemantic proximity Read ↗

The NOTCH1 and miR-34a signaling network is affected by TP53 alterations in CLL.Semantic proximity Read ↗

Expression level of miR-34a rather than P53 gene status correlates with mutability in related human lymphoblast cell lines.Semantic proximity Read ↗

Genome wide expression profiling of p53 regulated miRNAs in neuroblastomaSemantic proximity Read ↗

Gene expression profiling of 1p35-36 genes in neuroblastoma.Semantic proximity Read ↗

Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemiaSemantic proximity Read ↗

microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.