Article
Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells.
Oncogene - 26 Jan 2006
Tsai M-H, Chen X, Chandramouli G V R, Chen Y, Yan H, Zhao S, Keng P, Liber H L, Coleman C N, Mitchell J B, Chuang E Y
Abstract excerpt
The p53 protein has been implicated in multiple cellular responses related to DNA damage. Alterations in any of these cellular responses could be related to increased genomic instability. Our previous study has shown that mutations in p53 lead to hypermutability to ionizing radiation. To investigate further how p53 is involved in regulating mutational processes, we used 8K cDNA microarrays to compare the patterns...
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