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Wild-type p53 reduces radiation hypermutability in p53-mutated human lymphoblast cells.

Mutagenesis - 1 Sept 2007

Zhang Qinming, Liu Yunfeng, Zhou Junqing, Chen Weihong, Zhang Ying, Liber Howard L

Abstract excerpt

Many studies have shown that an alteration of p53 affects various cellular responses to DNA damage after treatment with ionizing radiation. The human lymphoblast cell WTK1, which contains a mutant p53 (ile237), is 10-fold hypermutable at the thymidine kinase (tk) locus compared with TK6 cells, which are from the same donor but contain wild-type p53. These results implied that the specific p53 mutation found in...

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PMID: 17567629
DOI: 10.1093/mutage/gem021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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