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Article

miR-34a as part of the resistance network in chronic lymphocytic leukemia

21 Oct 2008

Abstract excerpt

17p (TP53) deletion identifies patients with chronic lymphocytic leukemia (CLL) who are resistant to chemotherapy. The members of the miR-34 family have been discovered to be direct p53 targets and mediate some of the p53-dependent effects. We studied miR-34a and miR-34b/c expression in a large cohort to define their potential role in refractory CLL. While no expression of miR-34b/c could be detected, we found...

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PMID: 18941118
DOI: 10.1182/blood-2008-08-172254

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