Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of Shadoo protein in transgenic mice does not impact the pathogenesis of scrapie.

Neuroscience letters - 27 May 2011

Wang Haiying, Wan Jiayu, Wang Wei, Wang Dongxu, Li Sha, Liao Peng, Hao Zhuo, Wu Songbo, Xu Jing, Li Nan, Ouyang Hongsheng, Gao Hongwei

Abstract excerpt

Shadoo is a glycoprotein expressed in the adult brain that is an interacting protein of prion protein; however, its function remains to be determined. To elucidate its role in prion pathogenesis, we generated transgenic mice overexpressing wild-type (wt) Shadoo driven by the murine PrP promoter. Expression of the murine Sprn transgene significantly increased brain Shadoo protein levels in all three mouse lines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Glial Fibrillary Acidic Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GPI-Linked Proteins

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Nerve Tissue Proteins

Share to PrPSc Proteins

Share to Scrapie

Source

Identifiers

PMID: 21458534
DOI: 10.1016/j.neulet.2011.03.073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of Shadoo protein in transgenic mice does not impact the pathogenesis of scrapie.PMID 21458534Read ↗

Shadoo (Sprn) and prion disease incubation time in mice.Semantic proximity Read ↗

Frequent missense and insertion/deletion polymorphisms in the ovine Shadoo gene parallel species-specific variation in PrP.Semantic proximity Read ↗

Differential expression of Prnp and Sprn in scrapie infected sheep also reveals Prnp genotype specific differences.Semantic proximity Read ↗

Conserved stress-protective activity between prion protein and Shadoo.Semantic proximity Read ↗

Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein.Semantic proximity Read ↗

Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype.Semantic proximity Read ↗

Heparan sulfate proteoglycan is associated with amyloid plaques and neuroanatomically targeted PrP pathology throughout the incubation period of scrapie-infected mice.Semantic proximity Read ↗

Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.Semantic proximity Read ↗

New in vivo and ex vivo models for the experimental study of sheep scrapie: development and perspectives.Semantic proximity Read ↗

Susceptibility to scrapie in mice is dependent on PrPC.Semantic proximity Read ↗

Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent.Semantic proximity Read ↗

Comparative Analysis of the Shadoo Gene between Cattle and Buffalo Reveals Significant DifferencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.