Article
Shadoo (Sprn) and prion disease incubation time in mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2009
Lloyd Sarah E, Grizenkova Julia, Pota Hirva, Collinge John
Abstract excerpt
Prion diseases are transmissible neurodegenerative disorders of mammalian species and include scrapie, bovine spongiform encephalopathy (BSE), and variant Creutzfeldt-Jakob disease (vCJD). The prion protein (PrP) plays a key role in the disease, with coding polymorphism in both human and mouse influencing disease susceptibility and incubation time, respectively. Other genes are also thought to be important and a...
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