Article
Susceptibility to scrapie in mice is dependent on PrPC.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Mar 1994
Weissmann C, Büeler H, Fischer M, Sauer A, Aguet M
Abstract excerpt
Mice devoid of functional PrP genes (Prn-p(o/o) mice) showed normal development and behaviour. When inoculated with mouse scrapie prions they remained free of scrapie symptoms for at least 18 months whereas wild-type controls all died within 6 months. No propagation of infectivity could be detect...
Topics
- Animals
- Brain Chemistry
- Cricetinae
- Genetic Complementation Test
- Genotype
- Mesocricetus
- Mice
- Mice, Transgenic
- PrPSc Proteins
- Prions
- Scrapie
- Spleen