Article
Susceptibility to scrapie in mice is dependent on PrPC.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Mar 1994
Weissmann C, Büeler H, Fischer M, Sauer A, Aguet M
Abstract excerpt
Mice devoid of functional PrP genes (Prn-p(o/o) mice) showed normal development and behaviour. When inoculated with mouse scrapie prions they remained free of scrapie symptoms for at least 18 months whereas wild-type controls all died within 6 months. No propagation of infectivity could be detected in the PrP null mice. Surprisingly, heterozygous Prn-p(o/+) mice also showed enhanced resistance to scrapie. After...
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