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Article

Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein.

The Journal of biological chemistry - 26 Feb 2016

Nyeste Antal, Bencsura Petra, Vida István, Hegyi Zoltán, Homolya László, Fodor Elfrieda, Welker Ervin

Abstract excerpt

The prion protein (PrP) seems to exert both neuroprotective and neurotoxic activities. The toxic activities are associated with the C-terminal globular parts in the absence of the flexible N terminus, specifically the hydrophobic domain (HD) or the central region (CR). The wild type prion protein (PrP-WT), having an intact flexible part, exhibits neuroprotective qualities by virtue of diminishing many of the...

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Identifiers

PMID: 26721882
DOI: 10.1074/jbc.M115.679035
PMCID: PMC4813475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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