Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heparan sulfate proteoglycan is associated with amyloid plaques and neuroanatomically targeted PrP pathology throughout the incubation period of scrapie-infected mice.

Experimental neurology - 1 Feb 1998

McBride P A, Wilson M I, Eikelenboom P, Tunstall A, Bruce M E

Abstract excerpt

Heparan sulfate proteoglycan (HSPG) has been found to be associated with amyloid deposits in a number of diseases including the cerebral amyloid plaques of Alzheimer's disease and the transmissible spongiform encephalopathies (TSEs). The role of HSPG in amyloid formation and the neurodegenerative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Brain
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Immunohistochemistry

Share to Mice, Inbred Strains

Share to Reference Values

Source

Identifiers

PMID: 9500966
DOI: 10.1006/exnr.1997.6740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9500966-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heparan sulfate proteoglycan is associated with amyloid plaques and neuroanatomically targeted PrP pathology throughout the incubation period of scrapie-infected mice.PMID 9500966Read ↗

Neuronal <i>Ndst1</i> depletion accelerates prion protein clearance and slows neurodegeneration in prion infectionSemantic proximity Read ↗

Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.Semantic proximity Read ↗

Hereditary prion protein amyloidoses.Semantic proximity Read ↗

Altered glycosylated PrP proteins can have different neuronal trafficking in brain but do not acquire scrapie-like properties.Semantic proximity Read ↗

Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice.Semantic proximity Read ↗

A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.Semantic proximity Read ↗

The neuropathological phenotype in transgenic mice expressing different prion protein constructs.Semantic proximity Read ↗

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.Semantic proximity Read ↗

Overexpression of Shadoo protein in transgenic mice does not impact the pathogenesis of scrapie.Semantic proximity Read ↗

Characterization of splenic glycosaminoglycans accumulated in vivo in experimentally induced amyloid-susceptible and amyloid-resistant mice.Semantic proximity Read ↗

Prion protein (PrPc) promotes beta-amyloid plaque formation.Semantic proximity Read ↗

Heparin-like molecules bind differentially to prion-proteins and change their intracellular metabolic fate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.