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Comparative Analysis of the Shadoo Gene between Cattle and Buffalo Reveals Significant Differences

10 Oct 2012

Abstract excerpt

BACKGROUND: While prions play a central role in the pathogenesis of transmissible spongiform encephalopathies, the biology of these proteins and the pathophysiology of these diseases remain largely unknown. Since no case of bovine spongiform encephalopathy (BSE) has ever been reported in buffalo despite their phylogenetic proximity to cattle, genetic differences may be driving the different susceptibilities of...

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PMID: 23071594
DOI: 10.1371/journal.pone.0046601

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