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Article

Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.

Journal of medical genetics - 1 Dec 2008

Beck J A, Campbell T A, Adamson G, Poulter M, Uphill J B, Molou E, Collinge J, Mead S

Abstract excerpt

BACKGROUND: No susceptibility genes have been identified in human prion disase, apart from the prion protein gene (PRNP). The gene SPRN, encodes Shadoo (Sho, shadow of prion protein) which has protein homology and possible functional links with the prion protein. METHODS: A genetic screen was carried out of the open reading frame of SPRN by direct sequencing in 522 patients with prion disease, including 107 with...

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Source

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Identifiers

PMID: 18805828
DOI: 10.1136/jmg.2008.061804
PMCID: PMC2590874

Genes

SPRN
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.PMID 18805828Read ↗

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