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Article

New in vivo and ex vivo models for the experimental study of sheep scrapie: development and perspectives.

Comptes rendus biologies - 1 Jan 2002

Laude Hubert, Vilette Didier, Le Dur Annick, Archer Fabienne, Soulier Solange, Besnard Nathalie, Essalmani Rachid, Vilotte Jean-Luc

Abstract excerpt

Sheep scrapie is a prototypical transmissible spongiform encephalopathy (TSE), and the most widespread of these diseases. Experimental study of TSE infectious agents from sheep and other species essentially depends on bioassays in rodents. Transmission of natural sheep scrapie to conventional mice commonly requires one or two years. In an effort to develop laboratory models in which investigations on the sheep...

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PMID: 11862622
DOI: 10.1016/s1631-0691(02)01393-8

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