Article
Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent.
Neuron - 1 Nov 1995
Race R E, Priola S A, Bessen R A, Ernst D, Dockter J, Rall G F, Mucke L, Chesebro B, Oldstone M B
Abstract excerpt
To study the effect of cell type-restricted hamster PrP expression on susceptibility to the hamster scrapie agent, we generated transgenic mice using a 1 kb hamster cDNA clone containing the 0.76 kb HPrP open reading frame under control of the neuron-specific enolase promoter. In these mice, expr...
Topics
- Animals
- Base Sequence
- Cerebellum
- Cerebral Cortex
- Cricetinae
- DNA
- Dentate Gyrus
- Gene Expression
- Genetic Predisposition to Disease
- Hippocampus
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Neurons
- Prions
- RNA, Messenger
- Scrapie
- Thalamus