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Article

Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent.

Neuron - 1 Nov 1995

Race R E, Priola S A, Bessen R A, Ernst D, Dockter J, Rall G F, Mucke L, Chesebro B, Oldstone M B

Abstract excerpt

To study the effect of cell type-restricted hamster PrP expression on susceptibility to the hamster scrapie agent, we generated transgenic mice using a 1 kb hamster cDNA clone containing the 0.76 kb HPrP open reading frame under control of the neuron-specific enolase promoter. In these mice, expression of HPrP was detected only in brain tissue, with highest levels found in neurons of the cerebellum, hippocampus,...

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Identifiers

PMID: 7576660
DOI: 10.1016/0896-6273(95)90105-1
PMCID: PMC7135899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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