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Article

Conserved stress-protective activity between prion protein and Shadoo.

The Journal of biological chemistry - 18 Mar 2011

Sakthivelu Vignesh, Seidel Ralf P, Winklhofer Konstanze F, Tatzelt Jörg

Abstract excerpt

Shadoo (Sho) is a neuronally expressed glycoprotein of unknown function. Although there is no overall sequence homology to the cellular prion protein (PrP(C)), both proteins contain a highly conserved internal hydrophobic domain (HD) and are tethered to the outer leaflet of the plasma membrane via a C-terminal glycosylphosphatidylinositol anchor. A previous study revealed that Sho can reduce toxicity of a PrP...

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Identifiers

PMID: 21257747
DOI: 10.1074/jbc.M110.185470
PMCID: PMC3058987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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