Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent missense and insertion/deletion polymorphisms in the ovine Shadoo gene parallel species-specific variation in PrP.

PloS one - 6 Aug 2009

Daude Nathalie, Wohlgemuth Serene, Rogaeva Ekaterina, Farid A Hossein, Heaton Mike, Westaway David

Abstract excerpt

BACKGROUND: The cellular prion protein PrP(C) is encoded by the Prnp gene. This protein is expressed in the central nervous system (CNS) and serves as a precursor to the misfolded PrP(Sc) isoform in prion diseases. The prototype prion disease is scrapie in sheep, and whereas Prnp exhibits common missense polymorphisms for V136A, R154H and Q171R in ovine populations, genetic variation in mouse Prnp is limited....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Complementary
Share to GPI-Linked Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Nerve Tissue Proteins

Share to PrPC Proteins

Share to Sequence Homology, Amino Acid

Share to Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 19657386
DOI: 10.1371/journal.pone.0006538
PMCID: PMC2716538

Genes

SPRN
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent missense and insertion/deletion polymorphisms in the ovine Shadoo gene parallel species-specific variation in PrP.PMID 19657386Read ↗

Characterization of PRNP and SPRN coding regions from atypical scrapie cases diagnosed in Poland.Semantic proximity Read ↗

Influence of the prion protein gene, Prnp, on scrapie susceptibility in sheep.Semantic proximity Read ↗

Comparative Analysis of the Shadoo Gene between Cattle and Buffalo Reveals Significant DifferencesSemantic proximity Read ↗

Shadoo (Sprn) and prion disease incubation time in mice.Semantic proximity Read ↗

Ovine reference materials and assays for prion genetic testing.Semantic proximity Read ↗

The First Report of Genetic and Structural Diversities in the SPRN Gene in the Horse, an Animal Resistant to Prion Disease.Semantic proximity Read ↗

Identification of polymorphisms in the ovine Shadow of prion protein (SPRN) gene and assessment of their effect on promoter activity and susceptibility for classical scrapie.Semantic proximity Read ↗

Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep.Semantic proximity Read ↗

Identification of a novel lysine-171 allele in the ovine prion protein (PRNP ) gene.Semantic proximity Read ↗

Allelic variants of PRNP in 16 Chinese local sheep breeds.Semantic proximity Read ↗

Novel Polymorphisms and Genetic Characteristics of the Shadow of Prion Protein Gene (SPRN) in Cats, Hosts of Feline Spongiform Encephalopathy.Semantic proximity Read ↗

Nucleotide variants in prion-related protein (testis-specific) gene (PRNT) and effects on Chinese and Mongolian sheep phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.