Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Science (New York, N.Y.) - 25 Mar 2011

Zhang Ke, Fischer Tamas, Porter Rebecca L, Dhakshnamoorthy Jothy, Zofall Martin, Zhou Ming, Veenstra Timothy, Grewal Shiv I S

Abstract excerpt

Pervasive transcription of eukaryotic genomes generates a plethora of noncoding RNAs. In fission yeast, the heterochromatin factor Clr4/Suv39 methyltransferase facilitates RNA interference (RNAi)-mediated processing of centromeric transcripts into small interfering RNAs (siRNAs). Clr4 also mediates degradation of antisense RNAs at euchromatic loci, but the underlying mechanism has remained elusive. We show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Centromere
Share to Euchromatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Methyltransferases

Share to RNA, Antisense

Share to RNA, Fungal

Share to RNA Processing, Post-Transcriptional

Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21436456
DOI: 10.1126/science.1198712
PMCID: PMC6309853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.PMID 21436456Read ↗

Splicing factors facilitate RNAi-directed silencing in fission yeast.Semantic proximity Read ↗

Dicer independent small RNAs associate with telomeric heterochromatinSemantic proximity Read ↗

Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA.Semantic proximity Read ↗

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.Semantic proximity Read ↗

Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencing.Semantic proximity Read ↗

Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.Semantic proximity Read ↗

Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.Semantic proximity Read ↗

RNAi-mediated targeting of heterochromatin by the RITS complex.Semantic proximity Read ↗

Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.Semantic proximity Read ↗

RNAi-dependent formation of heterochromatin and its diverse functions.Semantic proximity Read ↗

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIVSemantic proximity Read ↗

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.