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Article

Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencing.

Molecular and cellular biology - 1 Jan 2008

Wang Shao-Win, Stevenson Abigail L, Kearsey Stephen E, Watt Stephen, Bähler Jürg

Abstract excerpt

Fission yeast Cid14, a component of the TRAMP (Cid14/Trf4-Air1-Mtr4 polyadenylation) complex, polyadenylates nuclear RNA and stimulates degradation by the exosome for RNA quality control. Here, we analyze patterns of global gene expression in cells lacking the Cid14 or the Dis3/Rpr44 subunit of the nuclear exosome. We found that transcripts from many genes induced during meiosis, including key regulators,...

Topics

Amino Acid Sequence
Centromere
Chromatin
Conserved Sequence
DNA, Ribosomal
Exoribonucleases
Exosome Multienzyme Ribonuclease Complex
Fungal Proteins
Gene Expression Profiling
Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Fungal

Molecular Sequence Data

Mutation

Polyadenylation

Polynucleotide Adenylyltransferase

RNA Interference

RNA, Nuclear

Schizosaccharomyces

Source

Open in PubMed Open full text

Identifiers

PMID: 18025105
DOI: 10.1128/MCB.01531-07
PMCID: PMC2223409

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