Article
Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2015
Chalamcharla Venkata R, Folco H Diego, Dhakshnamoorthy Jothy, Grewal Shiv I S
Abstract excerpt
Cotranscriptional RNA processing and surveillance factors mediate heterochromatin formation in diverse eukaryotes. In fission yeast, RNAi machinery and RNA elimination factors including the Mtl1-Red1 core and the exosome are involved in facultative heterochromatin assembly; however, the exact mechanisms remain unclear. Here we show that RNA elimination factors cooperate with the conserved exoribonuclease...
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