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Article

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.

Nature - 27 Jul 2017

Jih Gloria, Iglesias Nahid, Currie Mark A, Bhanu Natarajan V, Paulo Joao A, Gygi Steven P, Garcia Benjamin A, Moazed Danesh

Abstract excerpt

Heterochromatic DNA domains have important roles in the regulation of gene expression and maintenance of genome stability by silencing repetitive DNA elements and transposons. From fission yeast to mammals, heterochromatin assembly at DNA repeats involves the activity of small noncoding RNAs (sRNAs) associated with the RNA interference (RNAi) pathway. Typically, sRNAs, originating from long noncoding RNAs, guide...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28682306
DOI: 10.1038/nature23267
PMCID: PMC5576860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.PMID 28682306Read ↗

RNAi-dependent formation of heterochromatin and its diverse functions.Semantic proximity Read ↗

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Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.Semantic proximity Read ↗

Epigenetics. Restricted epigenetic inheritance of H3K9 methylation.Semantic proximity Read ↗

Heterochromatic genome stability requires regulators of histone H3 K9 methylation.Semantic proximity Read ↗

H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.Semantic proximity Read ↗

Analysis of a Rpb2 mutant in <i>Schizosaccharomyces pombe</i> reveals a non-canonical role for Elp1 in regulating RNAi-dependent heterochromatin assemblySemantic proximity Read ↗

LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decaySemantic proximity Read ↗

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