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Article

RNAi-mediated targeting of heterochromatin by the RITS complex.

Science (New York, N.Y.) - 30 Jan 2004

Verdel André, Jia Songtao, Gerber Scott, Sugiyama Tomoyasu, Gygi Steven, Grewal Shiv I S, Moazed Danesh

Abstract excerpt

RNA interference (RNAi) is a widespread silencing mechanism that acts at both the posttranscriptional and transcriptional levels. Here, we describe the purification of an RNAi effector complex termed RITS (RNA-induced initiation of transcriptional gene silencing) that is required for heterochromatin assembly in fission yeast. The RITS complex contains Ago1 (the fission yeast Argonaute homolog), Chp1 (a...

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Identifiers

PMID: 14704433
DOI: 10.1126/science.1093686
PMCID: PMC3244756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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RNAi-mediated targeting of heterochromatin by the RITS complex.PMID 14704433Read ↗

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.Semantic proximity Read ↗

Continuous requirement for the Clr4 complex but not RNAi for centromeric heterochromatin assembly in fission yeast harboring a disrupted RITS complex.Semantic proximity Read ↗

RNAi-dependent formation of heterochromatin and its diverse functions.Semantic proximity Read ↗

Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.Semantic proximity Read ↗

Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.Semantic proximity Read ↗

Splicing factors facilitate RNAi-directed silencing in fission yeast.Semantic proximity Read ↗

Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA.Semantic proximity Read ↗

A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation.Semantic proximity Read ↗

Ers1 links HP1 to RNAi.Semantic proximity Read ↗

Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation.Semantic proximity Read ↗

Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi.Semantic proximity Read ↗

Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.Semantic proximity Read ↗

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