Article
Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.
Nature structural & molecular biology - 4 Sept 2011
Reyes-Turcu Francisca E, Zhang Ke, Zofall Martin, Chen Eesin, Grewal Shiv I S
Abstract excerpt
Heterochromatin assembly at Schizosaccharomyces pombe centromeres involves a self-reinforcing loop mechanism wherein chromatin-bound RNAi factors facilitate targeting of Clr4-Rik1 methyltransferase. However, the initial nucleation of heterochromatin has remained elusive. We show that cells lacking Mlo3, a protein involved in mRNP biogenesis and RNA quality control, assemble functional heterochromatin in...
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