Article
Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA.
The EMBO journal - 16 Dec 2009
Djupedal Ingela, Kos-Braun Isabelle C, Mosher Rebecca A, Söderholm Niklas, Simmer Femke, Hardcastle Thomas J, Fender Aurélie, Heidrich Nadja, Kagansky Alexander, Bayne Elizabeth, Wagner E Gerhart H, Baulcombe David C, Allshire Robin C, Ekwall Karl
Abstract excerpt
The formation of heterochromatin at the centromeres in fission yeast depends on transcription of the outer repeats. These transcripts are processed into siRNAs that target homologous loci for heterochromatin formation. Here, high throughput sequencing of small RNA provides a comprehensive analysis of centromere-derived small RNAs. We found that the centromeric small RNAs are Dcr1 dependent, carry...
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