Article

TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV

2020-11-22

Abstract excerpt

The Human Silencing Hub (HUSH) complex constituted of TASOR, MPP8 and Periphilin is involved in the spreading of H3K9me3 repressive marks across genes and transgenes such as ZNF encoding genes, ribosomal DNAs, LINE-1, Retrotransposons and Retroelements or the integrated HIV provirus 1–5 . The deposit of these repressive marks leads to heterochromatin formation and inhibits gene expression. The precise mechanisms...

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Identifiers and source

Literature Corpus work: ba865a39-2ea2-5634-b295-9fb9ed2c817d
DOI: 10.1101/2020.11.22.386656

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